If you come from Budapest you have to take the exit to Görbeháza on motorway M3 to get to Debrecen on motorway M35. At Debrecen we suggest you to take the second exit to get to the city center the easiest way.
From Nyíregyháza you can get to Debrecen on highway nr. 4. It goes until Nagyállomás where you can park your car and start to discover the city on foot or with public transport.